Research Activities

Analytical Chemistry

Strong analytical science is a key requisite for a successful NCE-based drug discovery. PLSL is equipped with state-of-art analytical chemistry facilities for separation science, mass spectrometry and spectroscopy, including hyphenated techniques.

• Separation science makes use of HPLC with multiple detection systems, ELSD, HSGC-MS, and HPTLC, all managed through LIMS
• The spectroscopy facility has infrared mass spectrometry and NMR spectroscopy. Liquid chromatography is coupled with high-resolution quadruple Time-of-Flight MS (qTOF HR-LC/MS)
• MALDI-TOF/TOF MS is used to study protein-ligand interaction, identification of peptide profiles from clinical samples, and MS imaging of peptides from tissue samples
• The NMR facility provides a total spectroscopy solution for structural elucidation of new molecules and equipped with triple resonance probe
• Hyphenated techniques such as LC/MS, GC/MS and LC/MS/NMR are constantly being used for the analysis of low concentration of samples
• The circular dichroism facility is for prediction of secondary structure of proteins and rapid studies on protein-ligand interaction
• Automated differential scanning calorimetry and thermo-gravimetric analysis provide information on polymorphism of the drugs